左心室运动不能对心脏功能的影响。使用新模型的实验研究。

Effect of left ventricular akinesis on cardiac performance. Experimental study using a new model.

作者信息

Maggs P R, Nener T P, Ellis F H

出版信息

Circulation. 1979 May;59(5):1019-24. doi: 10.1161/01.cir.59.5.1019.

DOI:10.1161/01.cir.59.5.1019

Abstract

The understanding of left ventricular failure and cardiogenic shock after myocardial infarction has been facilitated by a two-component model proposed by Swan et al. which views the left ventricle as consisting of a clearly defined infarcted portion and a normally functioning remainder. Although appealing, this model is difficult to substantiate experimentally. We describe a new experimental preparation in which the infarct is stimulated by replacing part of the left ventricular wall with an inert patch of Dacron material. In 18 dogs studied after replacing varying amounts of left ventricular contractile mass with noncontractile patches, the left ventricular end-diastolic pressure rose in proportion to the size of the patch. Contractility was unchanged, and overall left ventricular pump function was normal. These data support the conceptual model. The experimental preparation is applicable to other studies of left ventricular akinesis.

摘要

斯旺等人提出的双组分模型有助于人们对心肌梗死后左心室衰竭和心源性休克的理解。该模型将左心室视为由明确界定的梗死部分和功能正常的其余部分组成。尽管该模型很有吸引力，但很难通过实验来证实。我们描述了一种新的实验方法，即用涤纶材料的惰性补片替换左心室壁的一部分来刺激梗死区域。在用非收缩性补片替换不同量的左心室收缩物质后，对18只狗进行了研究，结果显示左心室舒张末期压力与补片大小成比例升高。收缩性未发生变化，左心室整体泵功能正常。这些数据支持了该概念模型。这种实验方法适用于左心室运动不能的其他研究。