Harper P S
Birth Defects Orig Artic Ser. 1971 Jun;7(8):50-1.
More than one form of 'simple' hyperkeratosis palmaris et plantaris (tylosis) probably exists. Two unrelated patients showing hyperkeratosis of relatively late onset have been found who developed esophageal carcinoma, while previously reported families with dominantly inherited esophageal cancer and with esophageal stricture, also showed late onset of hyperkeratosis. In contrast the more usual families with onset of hyperkeratosis in the first six months of life show no association with esophageal or other disease.
可能存在不止一种形式的“单纯性”掌跖角化病（胼胝病）。已发现两名无亲缘关系的患者出现相对较晚发病的角化过度，他们后来患上了食管癌，而先前报道的具有显性遗传食管癌和食管狭窄的家族，也表现出角化过度发病较晚。相比之下，那些在出生后前六个月出现角化过度的较为常见的家族，与食管癌或其他疾病并无关联。
