乙醇戒断期间小鼠体内的生物胺与头部抽搐
Biogenic amines and head twitches in mice during ethanol withdrawal.
作者信息
Collier H O, Hammond M D, Schneider C
出版信息
Br J Pharmacol. 1974 Jun;51(2):310-1. doi: 10.1111/j.1476-5381.1974.tb09663.x.
Abstract
After chronic administration of ethanol to mice by the intragastric route head twitches occur as part of the ethanol withdrawal syndrome. Treatments which reduce brain 5-hydroxytryptamine or increase brain noradrenaline inhibited ethanol withdrawal head twitches, whereas treatments which increase brain 5-hydroxytryptamine or reduce brain noradrenaline were capable of inducing head twitches in control animals.
摘要
通过胃内途径对小鼠长期给予乙醇后，头部抽搐作为乙醇戒断综合征的一部分出现。降低脑5-羟色胺或增加脑去甲肾上腺素的处理可抑制乙醇戒断性头部抽搐，而增加脑5-羟色胺或降低脑去甲肾上腺素的处理能够在对照动物中诱导头部抽搐。
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Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents.某些新型药物对5-羟色胺的外周和中枢拮抗活性评估。
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