对氯苯丙氨酸对小鼠乙醇戒断期间脑单胺类物质及行为的影响。
Effect of p-chlorophenylalanine on brain monoamines and behaviour during ethanol withdrawal in mice.
作者信息
Griffiths P M, Littleton J M, Ortiz A
出版信息
Br J Pharmacol. 1974 Jun;51(2):307-9. doi: 10.1111/j.1476-5381.1974.tb09662.x.
The administration of p-chlorophenylalanine to mice prevents the rise in brain 5-hydroxytryptamine concentration associated with ethanol withdrawal but does not affect the increase in brain catecholamines which occurs at the same time. The locomotor excitement, piloerection, tremor and handling convulsions which occur during ethanol withdrawal were not affected. These results suggest that the increase in brain 5-hydroxytryptamine which occurs in ethanol withdrawal is a consequence of increased 5-hydroxytryptamine synthesis and that it is probably not involved in the above behavioural changes of ethanol withdrawal.
给小鼠施用对氯苯丙氨酸可防止与乙醇戒断相关的脑内5-羟色胺浓度升高，但不影响同时出现的脑内儿茶酚胺增加。乙醇戒断期间出现的运动兴奋、竖毛、震颤和处理惊厥均未受影响。这些结果表明，乙醇戒断时脑内5-羟色胺的增加是5-羟色胺合成增加的结果，并且它可能与乙醇戒断的上述行为变化无关。
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