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[临床、生物体液、形态学及仪器参数对某些慢性肝病诊断的贡献]

[Contribution of clinical, biohumoral, morphological and instrumental parameters to the diagnosis of some chronic liver diseases].

作者信息

Dobrilla G, Vantini I, Angelini G, Mirachian R, Cavallini G, Franchi R, Giorgetti G, Della Giustina L, Rosa B

出版信息

Quad Sclavo Diagn. 1974 Dec;10(4):491-508.

PMID:4282149
Abstract

A comparative study concerning the diagnostic importance of clinical, humoral, morphological and instrumental parameters had been carried out on 105 patients affected by chronic liver disease (51 cases with liver cirrhosis, 15 with metastatic tumors, 10 with liver steatosis and 29 with chronic hepatitis). The final diagnosis of the patients used for the comparison was formulated considering the greatest numbers of data. The results of this study can be drawn as follows: --clinical and laboratory data show satisfactory diagnostic value principally in patients suffering from liver cirrhosis (90 per ceny) and metastatic tumors (93 per cent); --peritoneoscopy appears to be generally the most useful procedure with the most significance value above all in cirrhotic patients; --morphological examination in biopsy specimen results of the greatest importance in patients affected by chronic hepatitis and hepatosteatosis while rather high has been the percentage of false negatives in secondary tumors of the liver (40 per cent) and cirrhosis (68 per cent); --scintiphotoscanning is generally less useful as a diagnostic tool than peritoneoscopy a part of the cases of metastatic tumors. In such a condition the diagnostic power of both the procedures results to be identical; --it may be concluded that an integrating diagnostic information generally results to be the most precise and maximally capable of reducing the number of false negatives. In individual cases, of course, the less important procedure shows to have the maximum of diagnostic capacity.

摘要

对105例慢性肝病患者(51例肝硬化、15例转移性肿瘤、10例肝脂肪变性和29例慢性肝炎)进行了一项关于临床、体液、形态学和仪器参数诊断重要性的比较研究。用于比较的患者的最终诊断是综合考虑大量数据后得出的。本研究结果如下:——临床和实验室数据主要在肝硬化患者(90%)和转移性肿瘤患者(93%)中显示出令人满意的诊断价值;——腹腔镜检查似乎总体上是最有用的检查方法,尤其在肝硬化患者中具有最重要的价值;——活检标本的形态学检查对慢性肝炎和肝脂肪变性患者最为重要,而在肝继发性肿瘤(40%)和肝硬化(68%)中假阴性率相当高;——闪烁扫描作为一种诊断工具,一般不如腹腔镜检查有用,但在部分转移性肿瘤病例中,两种检查方法的诊断能力相同;——可以得出结论,综合诊断信息通常最为准确,且最大程度地能够减少假阴性的数量。当然,在个别情况下,不太重要的检查方法也可能显示出最大的诊断能力。

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