Roda E, Roda A, Sama C, Festi D, Mazzella G, Aldini R, Barbara L
Dig Dis Sci. 1979 Feb;24(2):123-8. doi: 10.1007/BF01324739.
The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment, UDCA becomes the predominant biliary bile acid while chenodeoxycholic, cholic, and deoxycholic acid are significantly reduced. UDCA pool significantly increases, and chenodeoxycholic, cholic, and total bile acid pools significantly decrease. The reduction in bile lithogenicity during UDCA administration suggests that UDCA may be useful for cholesterol gallstone treatment in man.
对7例胆固醇结石患者给予熊去氧胆酸（UDCA）治疗1个月（12mg/kg/天）后，评估其对胆汁脂质成分和胆汁酸动力学的影响。给予UDCA可使胆固醇饱和指数（SI）显著降低。UDCA治疗后，UDCA成为主要的胆汁酸，而鹅去氧胆酸、胆酸和脱氧胆酸显著减少。UDCA池显著增加，鹅去氧胆酸、胆酸和总胆汁酸池显著减少。UDCA给药期间胆汁致石性降低表明，UDCA可能对人类胆固醇结石治疗有用。
