巯基化合物对缓激肽作用于平滑肌的增强机制。

Potentiating mechanism of bradykinin action on smooth muscle by sulfhydryl compounds.

作者信息

Iso T, Nishimura K, Oya M, Iwao J

出版信息

Eur J Pharmacol. 1979 Mar 1;54(3):303-5. doi: 10.1016/0014-2999(79)90091-8.

Abstract

(4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS-980), a potent angiotensin I (AI) converting enzyme inhibitor, inhibited the contractile response of isolated guinea-pig ileum to AI but not to AII, while it potentiated the response to bradykinin. Other sulfhydryl compuonds also produced inhibition of AI action, and the effects were closely correlated with their potentiating activities against bradykinin action. These results suggest that it is mainly inhibition of the enzyme in the tissue which participates in the mechanism of potentiation of kinin action by YS-980.

摘要

(4R)-3-[(2S)-3-巯基-2-甲基丙酰基]-4-噻唑烷羧酸（YS-980）是一种强效的血管紧张素I（AI）转化酶抑制剂，它能抑制离体豚鼠回肠对AI的收缩反应，但对AII无此作用，同时它能增强对缓激肽的反应。其他巯基化合物也能抑制AI的作用，且这些作用与它们对缓激肽作用的增强活性密切相关。这些结果表明，主要是组织中的酶受到抑制参与了YS-980增强激肽作用的机制。