Kajima M, Pollard M
J Bacteriol. 1965 Nov;90(5):1448-54. doi: 10.1128/jb.90.5.1448-1454.1965.
Kajima, Masahiro (University of Notre Dame, Notre Dame, Ind.), and Morris Pollard. Detection of viruslike particles in germ-free mice. J. Bacteriol. 90:1448-1454. 1965.-Viruslike particles similar in structure to the mouse leukemia agent were detected by electron microscopy in thymus tissues of germ-free AK mice which had developed spontaneous leukemia. In addition, unique viruslike particles (type B) were detected in tissues from spontaneous mammary adenocarcinoma of germ-free C3H mice. Leukemia virus-like particles were also observed in the thymuses of the control AK mice and of the C3H control mice as well as of those with mammary tumors. Germ-free mice are not virus-free. The routes of transmission of leukemia as well as of mammary tumor viruses may be "vertical," through the embryo or placenta.
岛正博(美国印第安纳州圣母大学)和莫里斯·波拉德。无菌小鼠中病毒样颗粒的检测。《细菌学杂志》90:1448 - 1454。1965年。——通过电子显微镜在自发发生白血病的无菌AK小鼠的胸腺组织中检测到结构与小鼠白血病病原体相似的病毒样颗粒。此外,在无菌C3H小鼠自发性乳腺腺癌的组织中检测到独特的病毒样颗粒(B型)。在对照AK小鼠、C3H对照小鼠以及患有乳腺肿瘤的小鼠的胸腺中也观察到白血病病毒样颗粒。无菌小鼠并非无病毒。白血病以及乳腺肿瘤病毒的传播途径可能是“垂直的”,通过胚胎或胎盘。