Prosser P R
Clin Exp Immunol. 1968 Mar;3(3):213-26.
Particles which morphologically resembled murine leukaemia virus were detected by electron microscopy in the tissues (spleen, thymus, inguinal lymph nodes, bone marrow or pancreas) but not in serum or plasma pellets of untreated conventional New Zealand Black (NZB) mice aged 1–82 weeks. They were also found in the corresponding tissues of NZB mice which had been thymectomized shortly after birth. The presence of similar particles in the spleen, thymus or pancreas of conventional NZB embryos and, additionally, in the lymph nodes of NZB mice which had originally been introduced into a germ-free environment by Caesarian section and fostering on germ-free mice of another strain, suggests that the virus is transmitted `vertically' through the germ cells or placenta. Preliminary investigations showed similar particles in the organs of conventional F (NZB × NZW) hybrid and New Zealand White (NZW) mice. Large numbers of particles also resembling murine leukaemia virus were found in the spleen and in plasma or serum pellets of young conventional NZB mice which had developed reticulum cell neoplasia following serial passage of lymphoid cell suspensions from ageing conventional NZB donors. The possible relationship of these particles to the autoimmune reactions and malignant changes which occur spontaneously in conventional NZB mice is discussed.
通过电子显微镜在1至82周龄未经处理的常规新西兰黑（NZB）小鼠的组织（脾脏、胸腺、腹股沟淋巴结、骨髓或胰腺）中检测到形态上类似于鼠白血病病毒的颗粒，但在血清或血浆沉淀中未检测到。在出生后不久进行胸腺切除的NZB小鼠的相应组织中也发现了这些颗粒。在常规NZB胚胎的脾脏、胸腺或胰腺中，以及最初通过剖腹产引入无菌环境并由另一品系的无菌小鼠饲养的NZB小鼠的淋巴结中存在类似颗粒，这表明该病毒通过生殖细胞或胎盘“垂直”传播。初步研究在常规F（NZB×NZW）杂种小鼠和新西兰白（NZW）小鼠的器官中发现了类似颗粒。在年轻的常规NZB小鼠的脾脏以及血浆或血清沉淀中也发现了大量类似鼠白血病病毒的颗粒，这些小鼠在连续传代老龄常规NZB供体的淋巴细胞悬液后发生了网状细胞肿瘤。讨论了这些颗粒与常规NZB小鼠中自发发生的自身免疫反应和恶性变化之间的可能关系。
