Egger G, Porta S
Exp Pathol (Jena). 1979;17(1):12-7. doi: 10.1016/s0014-4908(79)80004-6.
The influence of Isoproterenol on the number of the different types of white blood cells appearing during the course of the Sephadex inflammation was investigated in rats. Isoproterenol treatment causes a decrease of the number of the immigrating neutrophils within the first two days and an increase of the lymphocytes during almost the entire experiment. A sudden decrease of the number of these cell types, indicating a massive cell destruction, was followed by immigration of eosinophilic granulocytes after 24 hrs. Isoproterenol accelerated and augmented this immigration. We conclude, that perishing neutrophils and lymphocytes produce or mediate the production of factors which attract eosinophils and moreover that Isoproterenol enhances the production or the effect of these factors. The mechanism underlying this enhancement is not known. We suppose a specific beta-adrenergic influence, because we could not reproduce this increasing effect with adrenaline.
研究了异丙肾上腺素对大鼠在葡聚糖炎症过程中出现的不同类型白细胞数量的影响。异丙肾上腺素治疗导致在最初两天内迁移的中性粒细胞数量减少，并且在几乎整个实验过程中淋巴细胞数量增加。这些细胞类型数量的突然减少，表明大量细胞破坏，随后在24小时后嗜酸性粒细胞迁移。异丙肾上腺素加速并增强了这种迁移。我们得出结论，死亡的中性粒细胞和淋巴细胞产生或介导吸引嗜酸性粒细胞的因子的产生，而且异丙肾上腺素增强了这些因子的产生或作用。这种增强作用的潜在机制尚不清楚。我们推测是一种特定的β-肾上腺素能影响，因为我们不能用肾上腺素重现这种增加的效果。
