Gader A M, Cash J D
Scand J Haematol. 1975 Mar;14(1):5-10. doi: 10.1111/j.1600-0609.1975.tb00287.x.
Adrenaline, noradrenaline, isoprenaline and salbutamol were infused at the rate of 7 mug/min for 30 min into 5 healthy subjects. Pulse rates showed a marked increase after isoprenaline, a moderate increase after adrenaline and salbutamol, and a consistent decrease after noradrenaline. The total leucocyte counts increased in response to adrenaline and noradrenaline but remained unchanged after isoprenaline and salbutamol. The absolute lymphocyte counts showed significant increases after all the four agonists. Neutrophils increased in response to adrenaline and noradrenaline but remained unchanged after isoprenaline and salbutamol. 'Stress' lymphocyte counts rose in response to adrenaline, isoprenaline and salbutamol but not to noradrenaline. From these and other reported observations it is suggested that both alpha- and beta-receptors are involved in the mobolization of lymphocytes, while neither has any specific role in the mobilization of neutrophils.
将肾上腺素、去甲肾上腺素、异丙肾上腺素和沙丁胺醇以7微克/分钟的速率输注到5名健康受试者体内，持续30分钟。异丙肾上腺素注射后脉搏率显著增加，肾上腺素和沙丁胺醇注射后适度增加，而去甲肾上腺素注射后持续下降。肾上腺素和去甲肾上腺素使白细胞总数增加，而异丙肾上腺素和沙丁胺醇注射后白细胞总数保持不变。所有四种激动剂注射后，绝对淋巴细胞计数均显著增加。肾上腺素和去甲肾上腺素使中性粒细胞增加，而异丙肾上腺素和沙丁胺醇注射后中性粒细胞保持不变。“应激”淋巴细胞计数在肾上腺素、异丙肾上腺素和沙丁胺醇作用下升高，但在去甲肾上腺素作用下未升高。从这些以及其他已报道的观察结果表明，α和β受体均参与淋巴细胞的动员，而两者在中性粒细胞的动员中均无任何特定作用。
