Cascella D, Raffi G B, Caudarella R, Gennari P, Caprara C, Cipolla C
Minerva Med. 1979 Dec 1;70(54):3715-9.
A group of 20 chronic bronchopneumopathics was treated for 15 days with fenspiride orally and i.m. The behaviour of a set of functional respiratory and haemogasanalytic parameters was monitored at various times (basic, 5th, 10th and 15th days). Progressive, significant improvements in VC, FEV1, RV and in related parameters were observed. These were attributed to the drug's anti-inflammatory effect in the respiratory ways as well as to its direct antibronchospastic action. Stress is laid on the excellent clinical tolerance of fenspiride following its oral and i.m. administration.
一组20名慢性支气管肺炎患者接受了为期15天的口服和肌肉注射非那吡啶治疗。在不同时间（基础值、第5天、第10天和第15天）监测了一系列呼吸功能和血液气体分析参数的变化。观察到肺活量（VC）、第一秒用力呼气容积（FEV1）、残气量（RV）及相关参数有逐步显著改善。这些改善归因于该药物在呼吸道的抗炎作用及其直接的支气管解痉作用。强调了非那吡啶口服和肌肉注射后具有良好的临床耐受性。
