丝裂霉素C、其他抗生素及血清对溶原性细菌的活性。
Activity of mitomycin C, other antibiotics, and serum against lysogenic bacteria.
作者信息
Muschel L H, Schmoker K
出版信息
J Bacteriol. 1966 Oct;92(4):967-71. doi: 10.1128/jb.92.4.967-971.1966.
Muschel, Louis H. (University of Minnesota, Minneapolis), and Karen Schmoker. Activity of mitomycin C, other antibiotics, and serum against lysogenic bacteria. J. Bacteriol. 92:967-971. 1966.-Lysogenic bacteria were found to be more sensitive to the bactericidal action of mitomycin C or streptonigrin than the corresponding sensitive or indicator strains. This result may be attributed to the induction of phage production in lysogenic cells by these antibiotics. Lysogenic and sensitive bacteria were, however, equally sensitive to chloramphenicol, streptomycin, and polymyxin B. In contrast to their greater sensitivity to certain phage-inducing antibiotics, the lysogenic state resulted in greater resistance to the bactericidal reaction of serum mediated by the complement system. In general, therefore, the lysogenic state may result in either decreased or increased sensitivity to various antimicrobial agents.
马斯切尔，路易斯·H.（明尼苏达大学，明尼阿波利斯），以及凯伦·施莫克。丝裂霉素C、其他抗生素及血清对溶原性细菌的活性。《细菌学杂志》92:967 - 971。1966年。——发现溶原性细菌比相应的敏感菌或指示菌对丝裂霉素C或链黑菌素的杀菌作用更敏感。这一结果可能归因于这些抗生素诱导溶原性细胞产生噬菌体。然而，溶原性细菌和敏感细菌对氯霉素、链霉素和多粘菌素B的敏感性相同。与它们对某些噬菌体诱导抗生素的更高敏感性相反，溶原状态导致对补体系统介导的血清杀菌反应具有更大抗性。因此，一般来说，溶原状态可能导致对各种抗菌剂的敏感性降低或增加。
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