Kokko J P
Hosp Pract. 1979 Feb;14(2):110-6. doi: 10.1080/21548331.1979.11707487.
The capacity to elaborate urine either more dilute or more concentrated than the plasma from which it is derived enables the kidney to regulate the solute concentrations and hence the osmolality of body fluids within narrow physiologic limits despite wide fluctuations in salt and water intake. The underlying mechanisms are examined in detail, with emphasis on the role of urea in the countercurrent system of Henle's loop.
肾脏能够生成比其来源血浆更稀或更浓缩的尿液，这使得肾脏能够在盐和水摄入量大幅波动的情况下，将体液中的溶质浓度以及渗透压调节在狭窄的生理范围内。本文将详细探讨其潜在机制，重点关注尿素在亨氏袢逆流系统中的作用。
