人体内内源性D-葡糖二酸的生成及氨基比林的氧化N-去甲基化：缺乏相关性。

Production of endogenous D-glucaric acid and oxidative N-demethylation of amidopyrine in man: lack of correlation.

作者信息

Freundt K J

出版信息

Int J Clin Pharmacol Biopharm. 1979 Mar;17(3):104-6.

Abstract

In adult male subjects there was no positive correlation between the 24-hr urinary excretion of D-glucaric acid (D-GA) and the metabolic formation of 4-aminoantipyrine (AAP) from amidopyrine. It is concluded that in man the urinary D-GA excretion rate cannot be regarded in general as an indirect measure of the activity of microsomal drug conversion by means of mixed-function oxidases (MFO). Normal urinary value for D-GA: 16.3 +/- 1.5 (mean +/- SEM) mumols saccharo-1,4-lactone/24 hr as equivalent.

摘要

在成年男性受试者中，D - 葡糖醛酸（D - GA）的24小时尿排泄量与氨基比林代谢生成4 - 氨基安替比林（AAP）之间无正相关关系。得出结论：在人类中，一般不能将尿D - GA排泄率视为通过混合功能氧化酶（MFO）进行微粒体药物转化活性的间接测量指标。D - GA的正常尿值：16.3±1.5（平均值±标准误）微摩尔糖-1,4 - 内酯/24小时当量。