胆囊收缩素-促胰酶素C末端八肽的甲氧基类似物的合成及其生物活性
Syntheses and biological activities of methoxinine-analogues of the C-terminal octapeptide of cholecystokinin-pancreozymin.
作者信息
Gillessen D, Trzeciak A, Müller R K, Studer R O
出版信息
Int J Pept Protein Res. 1979 Feb;13(2):130-6. doi: 10.1111/j.1399-3011.1979.tb01860.x.
Abstract
The C-terminal octapeptide of cholecystokinin-pancreozymin and its analogues in which the methionine residues were successively replaced by methoxinine have been synthesized. When these analogues were tested for their gallbladder-contraction activity in an in vitro system the following relative potencies were observed: [Mox3]-CCK-PZ 8 (95%), [Mox6]-CCK-PZ 8 (5%) and [Mox3, Mox6]-CCK-PZ 8 (2%).
摘要
已合成胆囊收缩素-促胰酶素的C末端八肽及其甲硫氨酸残基被甲硫氨酸亚砜依次取代的类似物。当在体外系统中测试这些类似物的胆囊收缩活性时，观察到以下相对效价：[甲硫氨酸亚砜3]-胆囊收缩素-促胰酶素8（95%），[甲硫氨酸亚砜6]-胆囊收缩素-促胰酶素8（5%）和[甲硫氨酸亚砜3，甲硫氨酸亚砜6]-胆囊收缩素-促胰酶素8（2%）。
Zotero 插件