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胆囊收缩素C末端八肽、其三种类似物及蛙皮素在犬体内的生物活性

Biological activity of the C-terminal octapeptide of cholecystokinin, of three of its analogues and of caerulein in the dog.

作者信息

Meyer F D, Gyr K, Kayasseh L, Jeker L, Wall M, Trzeciak A, Gillessen D

出版信息

Experientia. 1980 Apr 15;36(4):434-6. doi: 10.1007/BF01975132.

DOI:10.1007/BF01975132
PMID:7379916
Abstract

Dose-response curves of the C-terminal octapeptide (CCK-8) of cholecystokinin, of 3 of its methoxinine analogues, and of caerulein for various variables of exocrine pancreatic secretion have been established in conscious dogs. The following relative potencies were calculated for the protein secretion activity of CCK-8 (100%), [Mox3]-CCK-8 (52%), [Mox6]-CCK-8 (27%), [Mox3,Mox6]-CCK-8 (19%) and caerulein (178%).

摘要

已在清醒犬中建立了胆囊收缩素的C末端八肽（CCK - 8）、其3种甲硫氨酸类似物以及蛙皮素对外分泌性胰腺分泌各种变量的剂量反应曲线。针对CCK - 8（100%）、[Mox3] - CCK - 8（52%）、[Mox6] - CCK - 8（27%）、[Mox3,Mox6] - CCK - 8（19%）和蛙皮素（178%）的蛋白质分泌活性计算了以下相对效力。

相似文献

1
Biological activity of the C-terminal octapeptide of cholecystokinin, of three of its analogues and of caerulein in the dog.胆囊收缩素C末端八肽、其三种类似物及蛙皮素在犬体内的生物活性
Experientia. 1980 Apr 15;36(4):434-6. doi: 10.1007/BF01975132.
2
Exocrine pancreatic secretion in response to a new CCK-analog, CCK33 and caerulein in dogs.
Regul Pept. 1984 Jul;8(4):291-6. doi: 10.1016/0167-0115(84)90038-7.
3
Bioactivity of cholecystokinin analogues: CCK-8 is not more potent than CCK-33.胆囊收缩素类似物的生物活性：八肽胆囊收缩素（CCK-8）的效力并不比三十三肽胆囊收缩素（CCK-33）更强。
Am J Physiol. 1984 Jul;247(1 Pt 1):G105-11. doi: 10.1152/ajpgi.1984.247.1.G105.
4
[Chemical structure and biological activity of cholecystokizin octapeptides with respect to the stomach and pancreas].[胆囊收缩素八肽对胃和胰腺的化学结构及生物活性]
Schweiz Med Wochenschr. 1980 May 31;110(22):861-2.
5
The release of pancreatic polypeptide by CCK-octapeptide and some analogues in the dog.狗体内胆囊收缩素八肽及一些类似物对胰多肽释放的影响。
Gastroenterology. 1981 Apr;80(4):742-7.
6
Glucose-dependent insulinotropic action of cholecystokinin and caerulein in the isolated perfused rat pancreas.胆囊收缩素和蛙皮素在离体灌注大鼠胰腺中的葡萄糖依赖性促胰岛素作用。
Endocrinology. 1982 Feb;110(2):398-402. doi: 10.1210/endo-110-2-398.
7
Cholecystokinin octapeptide, caerulein and caerulein analogues: effects on thermoregulation in the mouse.胆囊收缩素八肽、蛙皮素及蛙皮素类似物：对小鼠体温调节的影响。
Neuropharmacology. 1982 Aug;21(8):795-801. doi: 10.1016/0028-3908(82)90067-3.
8
Discrepancies between the doses of cholecystokinin or caerulein-stimulating exocrine and endocrine responses in perfused isolated rat pancreas.灌注分离的大鼠胰腺中胆囊收缩素或蛙皮素刺激外分泌和内分泌反应的剂量差异。
J Clin Invest. 1979 Mar;63(3):478-84. doi: 10.1172/JCI109325.
9
Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog.胆囊收缩素受体拮抗剂丙谷胺对犬蛙皮素刺激的胰腺酶分泌及胰多肽释放的影响。
Regul Pept. 1984 Mar;8(2):117-22. doi: 10.1016/0167-0115(84)90166-6.
10
Syntheses and biological activities of methoxinine-analogues of the C-terminal octapeptide of cholecystokinin-pancreozymin.胆囊收缩素-促胰酶素C末端八肽的甲氧基类似物的合成及其生物活性
Int J Pept Protein Res. 1979 Feb;13(2):130-6. doi: 10.1111/j.1399-3011.1979.tb01860.x.

本文引用的文献

1
Structure of porcine cholecystokinin-pancreozymin. 1. Cleavage with thrombin and with trypsin.猪胆囊收缩素-促胰酶素的结构。1. 用凝血酶和胰蛋白酶进行切割。
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2
Isolation and amino acid sequence of caerulein, the active decapeptide of the skin of hyla caerulea.雨蛙肽（caerulein）的分离及氨基酸序列，雨蛙（Hyla caerulea）皮肤中的活性十肽
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Synthesis of analogs of the C-terminal octapeptide of cholecystokinin-pancreozymin. Structure-activity relationship.
胆囊收缩素-促胰酶素C末端八肽类似物的合成。构效关系。
J Med Chem. 1970 May;13(3):349-52. doi: 10.1021/jm00297a003.
4
Cholecystokinin-pancreozymin: recent developments.胆囊收缩素-促胰酶素：近期进展
Am J Dig Dis. 1970 Feb;15(2):149-56. doi: 10.1007/BF02235646.
5
Comparison of synthetic and natural porcine secretins on human pancreatic secretion.合成猪促胰液素与天然猪促胰液素对人体胰腺分泌的比较。
Gastroenterology. 1974 Feb;66(2):204-9.
6
Pure cholecystokinin: pancreatic protein and bicarbonate response.纯胆囊收缩素：胰腺蛋白质和碳酸氢盐反应。
Digestion. 1973;9(6):469-81. doi: 10.1159/000197476.
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The endogenous release of pancreatic polypeptide by acid and meal in dogs. Effect of somatostatin.犬胃酸和进食引起的胰多肽内源性释放。生长抑素的作用。
Scand J Gastroenterol. 1978;13(4):385-91. doi: 10.3109/00365527809181911.
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Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog.胆囊收缩素的免疫化学研究。II. 人和猪中枢神经系统及小肠中的分布与分子异质性
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Syntheses and biological activities of methoxinine-analogues of the C-terminal octapeptide of cholecystokinin-pancreozymin.胆囊收缩素-促胰酶素C末端八肽的甲氧基类似物的合成及其生物活性
Int J Pept Protein Res. 1979 Feb;13(2):130-6. doi: 10.1111/j.1399-3011.1979.tb01860.x.
10
Species specificity of cholecystokinin in gut and brain of several mammalian species.几种哺乳动物肠道和大脑中胆囊收缩素的物种特异性
Proc Natl Acad Sci U S A. 1978 Jan;75(1):486-9. doi: 10.1073/pnas.75.1.486.