Wade J D, Ng F M, Bornstein J
Int J Pept Protein Res. 1979 Feb;13(2):195-200. doi: 10.1111/j.1399-3011.1979.tb01868.x.
Three peptides corresponding to the C-terminal region of human growth hormone have been synthesized by the solid-phase method: HGH-(177--191), HGH-(178--191) and HGH-(179--191). The diabetogenic activities of these synthetic peptides are reported. The data indicate that extension of HGH-(179--191) at its NH2-terminus is required for in vivo activity. The reduced and S-carbamidomethylated form of HGH-(177--191) was also active, indicating that the disulphide bond is possibly not a prerequisite for biological activity.
通过固相法合成了三种对应于人生长激素C末端区域的肽：HGH-(177--191)、HGH-(178--191)和HGH-(179--191)。报道了这些合成肽的致糖尿病活性。数据表明，HGH-(179--191)在其NH2末端的延伸是体内活性所必需的。HGH-(177--191)的还原型和S-氨甲酰甲基化形式也具有活性，这表明二硫键可能不是生物活性的先决条件。
