Schoenfeld C M, Conard G J, Lautenschlager E P
J Biomed Mater Res. 1979 Jan;13(1):135-47. doi: 10.1002/jbm.820130114.
The release of monomer from methylmethacrylate bone cements was studied during immersion in an aqueous environment intended to simulate in vivo polymerization of the material. Monomer release from disk-shaped specimens into an aqueous environment was assayed by gas chromatography. The simulated intracorporal polymerization was carried out under a variety of conditions intended to encompass possible clinical variables. The majority of monomer release occurred within the first 15 min of immersion. Under conditions generally recommended for commercial cements the release into aqueous media was always less than 3% of the total monomer weight. Clinically feasible options of delaying the time from onset of mixing of the cement to insertion into the host resulted in only a 0.7 wt % difference in the amount of released monomer. Measurements for a variety of monomer/powder ratios demonstrated a minimum in the amount of released monomer at a ratio of about 0.4 ml/g. In terms of unit area covered, thin specimens released less monomer than thick specimens.
在模拟材料体内聚合的水性环境中浸泡期间，对甲基丙烯酸甲酯骨水泥中单体的释放进行了研究。通过气相色谱法测定圆盘状试样在水性环境中的单体释放量。模拟体内聚合是在各种旨在涵盖可能临床变量的条件下进行的。大部分单体释放在浸泡的前15分钟内发生。在通常推荐用于商业骨水泥的条件下，向水性介质中的释放量始终小于单体总重量的3%。从骨水泥混合开始到植入宿主的时间延迟的临床可行选择，仅导致释放单体量有0.7 wt%的差异。对各种单体/粉末比例的测量表明，在约0.4 ml/g的比例下，释放单体的量最少。就覆盖的单位面积而言，薄试样释放的单体比厚试样少。
