Nichols M F, Hahn A W, Easley J R, Mayhan K G
J Biomed Mater Res. 1979 Mar;13(2):299-315. doi: 10.1002/jbm.820130210.
Plasma polymerized ethylene (PPE), styrene (PPS), and chlorotrifluoroethylene (PPCTFE) were synthesized by exposing the monomeric gases to an inductively coupled radio frequency "glow-discharge" field. The polymer films were deposited on poly(dimethyl) siloxane (medical grade Silastic), which was then surgically implanted in rat paravertebral muscle for periods up to 84 weeks. The biocompatibility of the plasma deposited films and uncoated Silastic was evaluated by qualitative (graded inflammatory cell response) and quantitative (connnective tissue capsule thickness) techniques as a function of time. The morphological features of the connective tissue capsule and the plasma polymerized films were examined by SEM after 75 weeks of implantation. Results showed that the acute inflammatory cell migration around PPS and PPCTFE was at a maximum in 2 weeks, decaying to control levels in 4 to 8 weeks. The PPE response was judged as less than the control response up to 4 weeks. After 8 weeks no qualitative difference could be detected between the plasma polymerized films and Silastic. On the other hand, a quantifiable change in fibrous capsule response as a function of time and material was noted until 24 weeks. From these data we conclude that these types of films do not elicit an untoward foreign body reaction at a skeletal muscle implant site in rats.
通过将单体气体暴露于电感耦合射频“辉光放电”场中，合成了等离子体聚合乙烯（PPE）、苯乙烯（PPS）和氯三氟乙烯（PPCTFE）。将聚合物薄膜沉积在聚（二甲基）硅氧烷（医用级硅橡胶）上，然后通过外科手术将其植入大鼠椎旁肌肉中长达84周。通过定性（分级炎症细胞反应）和定量（结缔组织囊厚度）技术，评估了等离子体沉积薄膜和未涂层硅橡胶的生物相容性随时间的变化。植入75周后，通过扫描电子显微镜检查结缔组织囊和等离子体聚合薄膜的形态特征。结果表明，PPS和PPCTFE周围的急性炎症细胞迁移在2周时达到最大值，在4至8周时降至对照水平。在4周内，PPE的反应被判定小于对照反应。8周后，在等离子体聚合薄膜和硅橡胶之间未检测到定性差异。另一方面，直到24周时，才观察到纤维囊反应随时间和材料的可量化变化。根据这些数据，我们得出结论，这些类型的薄膜在大鼠骨骼肌植入部位不会引发不良的异物反应。
