Miller P A, Milstrey K P, Trown P W
Science. 1968 Jan 26;159(3813):431-2. doi: 10.1126/science.159.3813.431.
Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.
