人肠道中1,25 - 二羟维生素D3的特异性胞质受体。
Specific cytosol receptors for 1,25-dihydroxyvitamin D3 in human intestine.
作者信息
Wecksler W R, Mason R S, Norman A W
出版信息
J Clin Endocrinol Metab. 1979 Apr;48(4):715-7. doi: 10.1210/jcem-48-4-715.
Human intestine is shown to contain a specific, high affinity cytosol receptor or binding protein for 1,25-(OH)2-vitamin D3 [1,25 (OH)2D3]. This receptor is a protein which sediments at 3.5S on sucrose gradients containing 0.3 M KCL. The receptor binds 1,25 (OH)2D3 with a Kd of approximately 2 x 10(-10) M at 4 degrees C. Competition binding studies using structural analogs of 1,25 (OH)2D3 indicate that the relative specificity of the receptor is 1,25 (OH)2D3 greater than 1,24R,25(OH)3D3 greater than greater than 25OHD3 1 OHD3 greater than 24R,25(OH)2D3.
研究表明，人体肠道含有一种特异性的、高亲和力的1,25-（OH）2-维生素D3 [1,25（OH）2D3]胞质溶胶受体或结合蛋白。该受体是一种蛋白质，在含有0.3M KCl的蔗糖梯度中沉降系数为3.5S。该受体在4℃时以约2×10（-10）M的解离常数（Kd）结合1,25（OH）2D3。使用1,25（OH）2D3结构类似物的竞争结合研究表明，该受体的相对特异性为1,25（OH）2D3大于1,24R,25（OH）3D3大于大于25OHD3 1 OHD3大于24R,25（OH）2D3。
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