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Effect of parathyroidectomy on serum 1 alpha,25-dihydroxyvitamin D and intestinal calcium absorption in primary hyperparathyroidism.

作者信息

Bone H G, Zerwekh J E, Haussler M R, Pak C Y

出版信息

J Clin Endocrinol Metab. 1979 May;48(5):877-9. doi: 10.1210/jcem-48-5-877.

DOI:10.1210/jcem-48-5-877
PMID:429532
Abstract

Serum concentration of 1 alpha,25-dihydroxyvitamin D [1,25(OH)2D] and intestinal absorption were measured before and after parathyroidectomy in 11 patients with primary hyperparathyroidism. Serum 1,25(OH)2D was high preoperatively (P less than 0.001) and normal postoperatively. Ca absorption was elevated preoperatively (P less than 0.001) and decreased significantly after parathyroidectomy (P less than 0.001). However, 5 of 11 patients had a persistent hyperabsorption of Ca postoperatively, despite normal serum 1,25(OH)2D. The results suggest that factors other than 1,25(OH)2D contribute to the maintenance of high intestinal Ca absorption in hyperparathyroid patients in the postoperative state.

摘要

相似文献

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引用本文的文献

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Metabolic effects of thiazide and 1,25-(OH)2 vitamin D in postmenopausal osteoporosis.噻嗪类药物和1,25-(OH)₂维生素D在绝经后骨质疏松症中的代谢作用
Osteoporos Int. 1993 Jul;3(4):209-14. doi: 10.1007/BF01623678.
2
Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism.假性甲状旁腺功能减退症中血清1α,25 - 二羟维生素D对甲状旁腺提取物无反应变化的证明。
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3
Tumoral calcinosis: evidence for concurrent defects in renal tubular phosphorus transport and in 1 alpha,25-dihydroxycholecalciferol synthesis.
肿瘤性钙化：肾小管磷转运及1α,25-二羟胆钙化醇合成同时存在缺陷的证据。
Calcif Tissue Int. 1980;32(1):1-6. doi: 10.1007/BF02408515.