甲状旁腺激素和低钙血症对人体1,25 - 二羟维生素D生成的刺激作用。

Stimulation of 1,25-dihydroxyvitamin D production by parathyroid hormone and hypocalcemia in man.

作者信息

Lund B, Sørensen O H, Lund B, Bishop J E, Norman A W

出版信息

J Clin Endocrinol Metab. 1980 Mar;50(3):480-4. doi: 10.1210/jcem-50-3-480.

Abstract

The serum levels of 1.25-dihydroxycholecalciferol [1,25(OH)2D3] were increased in five patients with primary hyperparathyroidism [60 +/- 13 (SD) pg/ml; normal value, 33 +/- 15 (SD) pg/ml] but fell rapidly after parathyroidectomy to values of 23 +/- 9 (SD) pg/ml. This was accompanied by parallel decreases in the serum concentrations of calcium and immunoreactive parathyroid hormone. Over the following 5--35 days, the serum 1,25(OH)2D3 concentrations increased markedly to levels of 59 +/- 17 (SD) pg/ml, which could most likely be explained by a stimulatory effect of the hypocalcemia per se on the renal production of 1,25(OH)2D3.

摘要

五例原发性甲状旁腺功能亢进患者的血清1,25 - 二羟胆钙化醇[1,25(OH)2D3]水平升高[60±13(标准差)pg/ml；正常值为33±15(标准差)pg/ml]，但甲状旁腺切除术后迅速降至23±9(标准差)pg/ml。同时血清钙和免疫反应性甲状旁腺激素浓度也相应下降。在接下来的5 - 35天内，血清1,25(OH)2D3浓度显著升高至59±17(标准差)pg/ml，这很可能是由于低钙血症本身对肾脏产生1,25(OH)2D3的刺激作用所致。