异戊烯基焦磷酸的改进合成法。
An improved synthesis of isopentenyl pyrophosphate.
作者信息
Donninger C, Popják G
出版信息
Biochem J. 1967 Nov;105(2):545-7. doi: 10.1042/bj1050545.
Abstract
- Isopentenol was converted into isopentenyl phosphate with phosphoryl chloride in ether containing pyridine. 2. The isopentenyl phosphate reacted in 2-methylpropan-2-ol-water with morpholine and dicyclohexylcarbodi-imide to give isopentenyl phosphoromorpholidate. 3. The isopentenyl phosphoromorpholidate, with inorganic phosphate in pyridine containing tributylamine, gave isopentenyl pyrophosphate. The yield of pyrophosphate from monophosphate was 80-85% and the yield of pyrophosphate from isopentenol 40-60%. [1-(14)C]-Isopentenyl pyrophosphate was prepared by this method. 4. The yield of isopentenyl pyrophosphate from isopentenyl phosphate was substantially improved, in comparison with the yields obtained by published methods via the phosphoramidate, by the use of the phosphoromorpholidate.
摘要
- 异戊烯醇在含吡啶的乙醚中与三氯氧磷反应转化为异戊烯基磷酸酯。2. 异戊烯基磷酸酯在2-甲基-2-丙醇-水体系中与吗啉和二环己基碳二亚胺反应生成异戊烯基磷酰吗啉。3. 异戊烯基磷酰吗啉在含三丁胺的吡啶中与无机磷酸盐反应生成异戊烯基焦磷酸。从单磷酸盐生成焦磷酸盐的产率为80 - 85%，从异戊烯醇生成焦磷酸盐的产率为40 - 60%。[1-(14)C]-异戊烯基焦磷酸就是用这种方法制备的。4. 与通过磷酰胺酯的已发表方法所获得的产率相比，通过使用磷酰吗啉，从异戊烯基磷酸酯生成异戊烯基焦磷酸的产率得到了显著提高。
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