Ondo J G, Pass K A
Endocrinology. 1976 May;98(5):1248-52. doi: 10.1210/endo-98-5-1248.
Several neurally active amino acids were injected into the third ventricle of anesthetized male rats. Two or eight mumole of GABA produced significant increases in the plasma concentrations of prolactin (PRL), indicating increased PRL release from the pituitary. Two mumole of glycine was also effective in elevating PRL levels. The intraventricular injection of the lowest dose of GABA (1.0 mumole), glutamate (0.4 or 2.3 mumole), lysine (0.2 or 2.0 mumole), or 0.9% NaCl did not alter PRL levels significantly. Plasma PRL concentrations did not increase following the injection of GABA or glycine directly into the anterior pituitary gland. The results suggest that GABA and glycine may play a role in the neural regulation of PRL secretion.
将几种具有神经活性的氨基酸注射到麻醉的雄性大鼠的第三脑室中。2或8微摩尔的γ-氨基丁酸（GABA）可使催乳素（PRL）的血浆浓度显著升高，表明垂体释放的PRL增加。2微摩尔的甘氨酸也能有效提高PRL水平。脑室内注射最低剂量的GABA（1.0微摩尔）、谷氨酸（0.4或2.3微摩尔）、赖氨酸（0.2或2.0微摩尔）或0.9%氯化钠溶液不会显著改变PRL水平。将GABA或甘氨酸直接注射到垂体前叶后，血浆PRL浓度并未升高。结果表明，GABA和甘氨酸可能在PRL分泌的神经调节中发挥作用。
