Ondo J G, Pass K A, Baldwin R
Neuroendocrinology. 1976;21(1):79-87. doi: 10.1159/000122514.
Several neurally excitant amino acids were injected into the third ventricle of anesthetized male rats, and plasma levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured. LH levels increased following injections of 2.0 mum glutamate, lysine, or beta-alanine. Glycine (2.0 mum), alpha-alanine (2.0 mum), and 0.9% saline were ineffective in altering LH levels. None of the amino acids tested significantly altered FSH levels. Of the 3 amino acids which raised blood LH levels following an intraventricular injection, i.e., glutamate, beta-alanine, and lysine, only lysine caused a significant increase in LH levels following injection into the pituitary. The present study provides evidence for a possible role for certain neurally excitant amino acids in the neuronal control of LH secretion.
将几种神经兴奋性氨基酸注入麻醉的雄性大鼠的第三脑室，并测量血浆中促黄体生成素（LH）和促卵泡激素（FSH）的水平。注射2.0 μmol谷氨酸、赖氨酸或β-丙氨酸后，LH水平升高。甘氨酸（2.0 μmol）、α-丙氨酸（2.0 μmol）和0.9%生理盐水对改变LH水平无效。所测试的氨基酸均未显著改变FSH水平。脑室内注射后能提高血液LH水平的3种氨基酸，即谷氨酸、β-丙氨酸和赖氨酸，只有赖氨酸注射到垂体后会使LH水平显著升高。本研究为某些神经兴奋性氨基酸在LH分泌的神经元控制中可能发挥的作用提供了证据。
