Chryssanthopoulos C, Maksud M G, Funahashi A, Hoffmann R G, Barboriak J J
J Allergy Clin Immunol. 1979 May;63(5):321-7. doi: 10.1016/0091-6749(79)90126-x.
The cardiorespiratory adjustments of asthmatic adults to submaximal and maximal workloads were investigated. Cardiorespiratory variables were measured every 2 min during exercise and at the end of maximal physical effort. Exercise-induced asthma (EIA) occurred in all asthmatic subjects while normal subjects maintained normal spirometry. The results suggest that asthmatic adults have no cardiac reserve or oxygen delivery limitations. They work under less efficient ventilatory conditions at submaximal workloads and have a significantly lower functional work capacity. The high degree of correlation between preexercise maximal midexpiratory flow rate (MMF) and maximum O2 consumption (max Vo2) suggests that the smaller airways contribute significantly to the observed abnormalities. We recommend that evaluation of antiasthmatic medications in exercise-induced asthma should take into consideration their effect upon smaller airways and cardiorespiratory variables.
对哮喘成年患者在次最大和最大负荷运动时的心肺调整情况进行了研究。在运动期间以及最大体力消耗结束时，每2分钟测量一次心肺变量。所有哮喘受试者均出现运动诱发性哮喘（EIA），而正常受试者的肺量计检查结果保持正常。结果表明，成年哮喘患者不存在心脏储备或氧输送限制。他们在次最大负荷运动时通气条件效率较低，且功能工作能力明显较低。运动前最大呼气中期流速（MMF）与最大耗氧量（max Vo2）之间的高度相关性表明，较小气道对所观察到的异常情况有显著影响。我们建议，在评估运动诱发性哮喘的抗哮喘药物时，应考虑其对较小气道和心肺变量的影响。
