缓激肽、血管紧张素和乙酰胆碱对牛肾上腺髓质的作用。

The effects of bradykinin, angiotensin and acetylcholine on the bovine adrenal medulla.

Comline R S, Silver M, Sinclair D G

J Physiol. 1968 May;196(2):339-50. doi: 10.1113/jphysiol.1968.sp008511.

Abstract

The response of the adrenal medulla to the intra-arterial injection of angiotensin, bradykinin and acetylcholine and to splanchnic nerve stimulation has been investigated in day-old and 3- to 18-month-old calves and in adult cats.2. Bradykinin and angiotensin had no appreciable effect on catecholamine release in the day-old calf nor did these peptides potentiate the response of the gland to acetylcholine.3. In older calves the response of the gland to bradykinin and angiotensin was marginally above the control output, whereas acetylcholine and splanchnic nerve stimulation caused a 10-100 fold increase in the rate of secretion. The response to acetylcholine but not to the peptides was related to the dose administered.4. The adrenal medulla of the cat was stimulated by angiotensin and bradykinin but the maximum amounts released by the peptides were much smaller than the discharge elicited either by splanchnic nerve stimulation or by acetylcholine. No dose-response relationship could be found for either adrenaline or noradrenaline released by angiotensin, or for noradrenaline released by bradykinin. The slight increase in adrenaline output which followed the injection of bradykinin was dependent on the dose but the slope of the curve (b = 0.161) was much less than that for acetylcholine (b = 0.636).

摘要

研究了新生犊牛、3至18月龄犊牛以及成年猫的肾上腺髓质对动脉内注射血管紧张素、缓激肽和乙酰胆碱以及对内脏神经刺激的反应。
缓激肽和血管紧张素对新生犊牛的儿茶酚胺释放没有明显影响，这些肽也不能增强肾上腺髓质对乙酰胆碱的反应。
在年龄较大的犊牛中，肾上腺髓质对缓激肽和血管紧张素的反应略高于对照输出量，而乙酰胆碱和内脏神经刺激导致分泌速率增加10至100倍。对乙酰胆碱的反应而非对这些肽的反应与给药剂量有关。
猫的肾上腺髓质受到血管紧张素和缓激肽的刺激，但这些肽释放的最大量远小于内脏神经刺激或乙酰胆碱引起的释放量。血管紧张素释放的肾上腺素或去甲肾上腺素，以及缓激肽释放的去甲肾上腺素，均未发现剂量反应关系。注射缓激肽后肾上腺素输出量的轻微增加取决于剂量，但曲线斜率（b = 0.161）远小于乙酰胆碱的曲线斜率（b = 0.636）。