儿茶酚胺对肾上腺传入神经单位活动的影响。
The effect of catecholamines on unit activity in afferent nerves from the adrenal glands.
作者信息
Niijima A, Winter D L
出版信息
J Physiol. 1968 Apr;195(3):647-56. doi: 10.1113/jphysiol.1968.sp008480.
Abstract
- Afferent discharges were observed in dissected filaments of nerves to the adrenal gland in the rabbit and cat.2. Systemic intravenous and close intra-arterial injections of (-)-adrenaline and (-)-noradrenaline caused cessation or depression of the spontaneous firing rate.3. Intravenous injection of acetylcholine and electrical stimulation of the splanchnic nerve also depressed the afferent discharge rate.4. Modification of blood pressure levels by chemical and mechanical means did not modify the afferent discharge.5. Alpha blocking agents (ergotamine and phenoxybenzamine) blocked the effect of (-)-adrenaline on the firing rate. Beta blocking agents (dichloroisoprenaline and propranolol) were without effect.6. It is suggested that an afferent system is present in the adrenal gland. Within this system are chemosensitive receptors which may constitute the afferent limb of a local feed-back loop involved in adrenal catecholamine release.
摘要
在兔和猫身上，观察到了通向肾上腺的神经细丝中的传入放电。
全身静脉注射和动脉内近距离注射（-）-肾上腺素和（-）-去甲肾上腺素会导致自发放电率停止或降低。
静脉注射乙酰胆碱和内脏神经的电刺激也会降低传入放电率。
通过化学和机械手段改变血压水平并不会改变传入放电。
α受体阻断剂（麦角胺和苯氧苄胺）阻断了（-）-肾上腺素对放电率的影响。β受体阻断剂（二氯异丙肾上腺素和普萘洛尔）则没有效果。
提示肾上腺中存在一个传入系统。在这个系统中存在化学敏感受体，它们可能构成参与肾上腺儿茶酚胺释放的局部反馈回路的传入部分。
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