雌激素和孕酮对大鼠血管紧张素升压作用的影响。
The effect of oestrogen and progesterone on the pressor action of angiotensin in the rat.
作者信息
Hettiaratchi E S, Pickford M
出版信息
J Physiol. 1968 May;196(2):447-51. doi: 10.1113/jphysiol.1968.sp008517.
Abstract
- A comparison was made between the pressor responses to angiotensin in rats during different stages of the oestrous cycle, pregnancy, pseudopregnancy and also following oestrogen and progesterone treatment.2. No evidence for an effect of oestrogen on the response to angiotensin was found.3. Pregnancy and pseudopregnancy were found to diminish the pressor response to angiotensin.4. Progesterone treatment also diminished the response to angiotensin.5. It is suggested that the decrease in pressor response in pregnancy and pseudopregnancy is attributable to progesterone.6. The possible mode of action of progesterone is discussed.
摘要
对处于发情周期不同阶段、怀孕期、假孕状态的大鼠以及接受雌激素和孕酮治疗后的大鼠，就其对血管紧张素的升压反应进行了比较。
未发现雌激素对血管紧张素反应有影响的证据。
发现怀孕和假孕会减弱对血管紧张素的升压反应。
孕酮治疗也会减弱对血管紧张素的反应。
有人提出，怀孕和假孕时升压反应的降低归因于孕酮。
讨论了孕酮可能的作用方式。
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