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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Senior J, Whalley E T

J Physiol. 1976 Mar;256(1):167-74. doi: 10.1113/jphysiol.1976.sp011318.

Changes in the plasma kinin precursor, kininogen, occur following treatment with oestrogens and progestogens. This work was undertaken to attempt to relate plasma kininogen values to hormonal changes in various reproductive states. 2. During the oestrous cycle kininogen concentrations follow a nychthemeral rhythm, kininogen depletion occurring during the increase in general activity of the rat. 3. Superimposed on the nychthemeral changes in kininogen concentration are changes which may be related to the hormonal events of the oestrous cycle. 4. During early pregnancy and pseudopregnancy the kininogen level rises; this increase may be due to changes in the circulating levels of oestrogens and progestogens. 5. It is suggested that the changes in kininogen concentration may result from utilization of kinin which could be of functional significance.

用雌激素和孕激素治疗后，血浆激肽原前体即激肽原会发生变化。开展这项研究旨在尝试将血浆激肽原值与各种生殖状态下的激素变化联系起来。2. 在发情周期中，激肽原浓度呈现昼夜节律，在大鼠总体活动增加期间激肽原会减少。3. 叠加在激肽原浓度昼夜变化之上的是可能与发情周期激素事件相关的变化。4. 在妊娠早期和假孕期间，激肽原水平升高；这种升高可能是由于雌激素和孕激素循环水平的变化。5. 有人提出，激肽原浓度的变化可能是由于激肽的利用，这可能具有功能意义。

Senior J, Whalley E T

J Physiol. 1976 Mar;256(1):167-74. doi: 10.1113/jphysiol.1976.sp011318.

Changes in the plasma kinin precursor, kininogen, occur following treatment with oestrogens and progestogens. This work was undertaken to attempt to relate plasma kininogen values to hormonal changes in various reproductive states. 2. During the oestrous cycle kininogen concentrations follow a nychthemeral rhythm, kininogen depletion occurring during the increase in general activity of the rat. 3. Superimposed on the nychthemeral changes in kininogen concentration are changes which may be related to the hormonal events of the oestrous cycle. 4. During early pregnancy and pseudopregnancy the kininogen level rises; this increase may be due to changes in the circulating levels of oestrogens and progestogens. 5. It is suggested that the changes in kininogen concentration may result from utilization of kinin which could be of functional significance.

用雌激素和孕激素治疗后，血浆激肽原前体即激肽原会发生变化。开展这项研究旨在尝试将血浆激肽原值与各种生殖状态下的激素变化联系起来。2. 在发情周期中，激肽原浓度呈现昼夜节律，在大鼠总体活动增加期间激肽原会减少。3. 叠加在激肽原浓度昼夜变化之上的是可能与发情周期激素事件相关的变化。4. 在妊娠早期和假孕期间，激肽原水平升高；这种升高可能是由于雌激素和孕激素循环水平的变化。5. 有人提出，激肽原浓度的变化可能是由于激肽的利用，这可能具有功能意义。