硫唑嘌呤（依木兰）给药与NZB小鼠恶性淋巴瘤的发生
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.
作者信息
Casey T P
出版信息
Clin Exp Immunol. 1968 May;3(4):305-12.
Abstract
Azathioprine in doses that made NZB mice more anaemic did not cause reversal of their positive Coombs tests. When given to young NZB mice it did not delay development of the Coombs positive state. Azathioprine had a carcinogenic effect. Six out of eight NZB mice treated from the age of 2 months developed malignant lymphomas particularly involving the thymus. Caution is suggested in the use of immunosuppressant agents in non-malignant conditions, especially in the young, until the risk of carcinogenesis has been evaluated.
摘要
给予使新西兰黑鼠（NZB）贫血加重剂量的硫唑嘌呤，并未使其阳性库姆斯试验结果逆转。给予幼年NZB鼠时，并未延迟其库姆斯阳性状态的发展。硫唑嘌呤具有致癌作用。从2月龄开始接受治疗的8只NZB鼠中有6只发生了恶性淋巴瘤，尤其累及胸腺。在非恶性疾病中使用免疫抑制剂时应谨慎，特别是在幼年患者中，直到致癌风险得到评估。
相似文献
1
Azathioprine (Imuran) administration and the development of malignant lymphomas in NZB mice.硫唑嘌呤（依木兰）给药与NZB小鼠恶性淋巴瘤的发生
Clin Exp Immunol. 1968 May;3(4):305-12.
2
3
The thymoma-prone (NZB X CFW) F1 mouse.易患胸腺瘤的（新西兰黑鼠×CFW 鼠）F1 代小鼠。
J Pathol. 1971 Mar;103(3):188-93. doi: 10.1002/path.1711030308.
4
[Development of autoimmune disease in NZB-BLN mice].[NZB - BLN小鼠自身免疫性疾病的发展]
Zh Obshch Biol. 1972 Jul-Aug;33(4):484-92.
5
Immunopathology of New Zealand Black mice treated with antilymphocyte globulin.用抗淋巴细胞球蛋白治疗的新西兰黑鼠的免疫病理学
Immunology. 1971 Jun;20(6):973-1000.
6
Lactoferrin lowers the incidence of positive Coombs' test in New Zealand black mice.乳铁蛋白降低了新西兰黑鼠抗人球蛋白试验阳性的发生率。
Arch Immunol Ther Exp (Warsz). 1995;43(3-4):207-9.
7
8
[NZB mice].[新西兰黑鼠]
Pathol Biol. 1968 Oct;16(19):885-92.
9
Autoimmune hemolytic anemia in a dog.
J Am Vet Med Assoc. 1973 Jan 1;162(1):45-6.
引用本文的文献
1
Malignancy and systemic lupus erythematosus.恶性肿瘤与系统性红斑狼疮
Curr Rheumatol Rep. 2002 Aug;4(4):351-8. doi: 10.1007/s11926-002-0045-6.
2
The complications of antilymphocyte therapy.抗淋巴细胞疗法的并发症。
Proc R Soc Med. 1970 Oct;63(10):1067-8. doi: 10.1177/003591577006301051.
3
Further experience with azathioprine in rheumatoid arthritis.硫唑嘌呤治疗类风湿性关节炎的更多经验
Br Med J. 1971 Nov 20;4(5785):463-4. doi: 10.1136/bmj.4.5785.463.
4
Anti-lymphocytic antibody and autoimmune disease: a review.抗淋巴细胞抗体与自身免疫性疾病：综述
Clin Exp Immunol. 1969 Sep;5(3):217-49.
5
Malignant lymphomas in transplantation patients.移植患者中的恶性淋巴瘤。
Transplant Proc. 1969 Mar;1(1):106-12.
6
7
Malignant lymphomas in transplantation patients: a review of the world experience.移植患者中的恶性淋巴瘤：全球经验综述
Int Z Klin Pharmakol Ther Toxikol. 1970 Jan;3(1):49-54.
8
Nephrotic syndrome due to primary renal disease in adults: II. A controlled trial of prednisolone and azathioprine.成人原发性肾脏疾病所致肾病综合征：II. 泼尼松龙与硫唑嘌呤的对照试验
Br Med J. 1969 May 31;2(5656):535-9. doi: 10.1136/bmj.2.5656.535.
9
Lymphocyte responses to phytohemagglutinin in rheumatoid arthritis and glomerulonephritis and the effects of immunosuppression.
Experientia. 1973 May 15;29(5):606-7. doi: 10.1007/BF01926694.
10
Immunosuppression and malignancy.免疫抑制与恶性肿瘤。
Br Med J. 1972 Sep 23;3(5829):713-4.
本文引用的文献
1
2
THE NATURAL HISTORY OF AUTOIMMUNE DISEASE IN NZB MICE. A COMPARISON WITH THE PATTERN OF HUMAN AUTOIMMUNE MANIFESTATIONS.新西兰黑鼠自身免疫性疾病的自然史。与人类自身免疫表现模式的比较。
Ann Intern Med. 1963 Sep;59:265-76. doi: 10.7326/0003-4819-59-3-265.
3
Spontaneous auto-immune disease in NZB/BL mice.NZB/BL小鼠的自发性自身免疫疾病。
Br J Haematol. 1963 Apr;9:119-31. doi: 10.1111/j.1365-2141.1963.tb05450.x.
4
Studies on the character and staining of fibrin.纤维蛋白的特性及染色研究。
J Clin Pathol. 1962 Sep;15(5):401-13. doi: 10.1136/jcp.15.5.401.
5
Immune reactivity prior to development of thymic lymphoma in C57BL mice.C57BL小鼠胸腺淋巴瘤发生前的免疫反应性。
Int J Cancer. 1967 Mar 15;2(2):103-8. doi: 10.1002/ijc.2910020205.
6
7
8
Symposium on immunosuppressive drugs. Late effects of immunosuppressive anticancer drugs.免疫抑制药物研讨会。免疫抑制抗癌药物的远期效应。
Fed Proc. 1967 May-Jun;26(3):925-33.
9
Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues.免疫抑制药物研讨会。嘌呤类似物的生物化学与药理学
Fed Proc. 1967 May-Jun;26(3):898-904.
10
Autoimmune disease in NZB-Bl mice. II. Autoimmunity and malignant lymphoma.NZB-Bl小鼠的自身免疫性疾病。II.自身免疫与恶性淋巴瘤。
Blood. 1966 Apr;27(4):435-48.
Zotero 插件