Denman A M, Russell A S, Loewi G, Denman E J
Immunology. 1971 Jun;20(6):973-1000.
Antilymphocytic globulin (ALG) suppressed the development of haemolytic anaemia with positive antiglobulin (Coombs) reactions in intact and adult thymectomized New Zealand Black (NZB) mice, although some recipients eventually became positive after treatment was stopped. Macroglobulinaemia and lymphoid cell infiltrates were resistant and complex nephritis was unaffected by, and in thymectomized recipients accelerated by, ALG, whilst many such recipients developed severe Coombs negative haemolytic anaemia. Splenomegaly was less pronounced in ALG treated than in control NZB mice. However, lymphoproliferative changes in general, and reticulum cell hyperplasia in particular, progressed despite ALG treatment in early life. On the other hand, this agent did not provoke overt neoplasia in the lymphatic or other tissues. Syngeneic lymphoid cells from young donors did not influence the disease of ALG treated mice but rat lymphoid cells in thymectomized recipients induced a temporary suppression of macroglobulinaemia and reticulum cell proliferation was reduced.
抗淋巴细胞球蛋白（ALG）抑制了完整的和成年后切除胸腺的新西兰黑（NZB）小鼠中伴有阳性抗球蛋白（库姆斯）反应的溶血性贫血的发展，尽管一些接受治疗的小鼠在停药后最终还是呈阳性。巨球蛋白血症和淋巴细胞浸润具有抗药性，而复杂性肾炎不受ALG影响，在切除胸腺的受体中反而会加速发展，同时许多此类受体出现严重的库姆斯阴性溶血性贫血。与对照NZB小鼠相比，接受ALG治疗的小鼠脾肿大不那么明显。然而，尽管在生命早期进行了ALG治疗，但总体的淋巴细胞增殖变化，尤其是网状细胞增生仍在进展。另一方面，该药物不会在淋巴组织或其他组织中引发明显的肿瘤形成。来自年轻供体的同基因淋巴细胞不会影响接受ALG治疗的小鼠的疾病，但切除胸腺的受体中的大鼠淋巴细胞会导致巨球蛋白血症的暂时抑制，并且网状细胞增殖减少。
