群体中的人类白细胞抗原：癌症遗传易感性的一种研究方法。

HLA in populations: an approach for genetical susceptibility to cancer.

作者信息

Feingold N, Degos L, Feingold J

出版信息

J Immunogenet. 1979 Feb;6(1):29-35. doi: 10.1111/j.1744-313x.1979.tb00673.x.

DOI:10.1111/j.1744-313x.1979.tb00673.x

Abstract

The geographical correlations between the incidence of various cancers and the HLA and ABO antigen frequencies are studied. There is, for example, a positive correlation between breast and colorectal carcinoma and AI, B8 and B12 antigens, and a negative one between prostate carcinoma and B12. The role of the HLA system itself or other genes involved in these associations is discussed. This study gives some evidence of a possible genetic background of susceptibility or resistance to cancer.

摘要

研究了各种癌症的发病率与HLA及ABO抗原频率之间的地理相关性。例如，乳腺癌和结直肠癌与A1、B8和B12抗原呈正相关，而前列腺癌与B12呈负相关。文中讨论了HLA系统本身或参与这些关联的其他基因的作用。这项研究为癌症易感性或抗性可能存在的遗传背景提供了一些证据。