Greenacre M J, Degos L
Am J Hum Genet. 1977 Jan;29(1):60-75.
Correspondence analysis, a variant of principal components analysis, is used to interpret and compare gene frequencies of the HLA system for 124 samples from different populations studied in the Fifth and Sixth International Histocompatibility Workshops. The major advantage of this analysis is that populations and HLA genes are represented simultaneously with respect to the same axes in multidimensional space. This permits the visual interpretation of genetic differences between populations, the relative participation of each gene in the dispersion, and the correspondence between populations and genes. By this method a clear separation of ethnic groups in the world is obtained. Furthermore, within Europe the separation of samples from different countries is concordant with their geographical distances. The HLA system appears sufficiently polymorphic to define a population by its gene frequencies.
对应分析是主成分分析的一种变体，用于解释和比较在第五届和第六届国际组织相容性研讨会上研究的来自不同人群的124个样本的HLA系统基因频率。该分析的主要优点是，在多维空间中，人群和HLA基因在同一轴上同时得到表示。这使得可以直观地解释人群之间的遗传差异、每个基因在离散中的相对参与度以及人群与基因之间的对应关系。通过这种方法，可以清楚地将世界上的不同种族区分开来。此外，在欧洲范围内，来自不同国家的样本的区分与其地理距离一致。HLA系统似乎具有足够的多态性，能够通过其基因频率来界定一个人群。
