Feldman D, Gross L, Swarm R L
Cancer Res. 1976 May;36(5):1814-20.
Examination of yolk sac from a C3Hf and a C3H mouse with the electron microscope revealed the presence of C-type virus particles in the blood islands. Particles were observed budding from the plasma membrane of hemocytoblasts, from erythroblasts, and occasionally from reticulocytes. C-type particles were also found in similar cells in hematopoietic foci in the liver, spleen, and bone marrow of embryos, and they continued to be present in newborn C3Hf mice up to 11 days of age. Particles consistently appeared in the thymus, even in older suckling mice. A comparison is made between the presence of C-type particles in organs of embryonic, newborn, and adult C3Hf mice. C-type particles were not observed in the chorioallantoic placentas from mice that were given injections of mouse leukemia virus (Gross) or from normal noninjected mice; however, intracisternal A-type particles were present in cytotrophoblast cells from these placentas.
用电子显微镜检查C3Hf和C3H小鼠的卵黄囊，发现血岛中存在C型病毒颗粒。观察到颗粒从成血细胞、幼红细胞的质膜出芽，偶尔也从网织红细胞出芽。在胚胎的肝脏、脾脏和骨髓造血灶的类似细胞中也发现了C型颗粒，并且在新生C3Hf小鼠中一直存在至11日龄。颗粒始终出现在胸腺中，即使在较大的乳鼠中也是如此。对胚胎、新生和成年C3Hf小鼠器官中C型颗粒的存在情况进行了比较。在注射了小鼠白血病病毒（格罗斯株）的小鼠或未注射的正常小鼠的绒毛尿囊胎盘组织中未观察到C型颗粒；然而，这些胎盘的细胞滋养层细胞中存在核内A型颗粒。
