1-甲基异靛红3-硫代半卡巴腙对新西兰黑鼠与新西兰白鼠杂交小鼠的治疗
1-Methylisatin 3-thiosemicarbazone treatment of NZB x NZW hybrid mice.
作者信息
Gabriel R
出版信息
Br J Exp Pathol. 1971 Jun;52(3):271-5.
Abstract
Female B/W mice have been treated with the anti-viral agent 1-Methylisatin 3-Thiosemicarbazone. The drug was given upon the day of birth and weekly until death. There was a delay in the development of proteinuria and positive antinuclear factor. The mean survival of the group was prolonged; eventually all mice died from nephritis within a 6 week period. The results are interpreted as a suppression of viral activity in these animals.
摘要
雌性黑白花小鼠已接受抗病毒药物1-甲基异靛蓝3-硫代半卡巴腙的治疗。该药物在出生当天给药，每周给药一次直至死亡。蛋白尿和抗核因子阳性的发展出现延迟。该组小鼠的平均生存期延长；最终所有小鼠在6周内死于肾炎。这些结果被解释为该药物对这些动物体内病毒活性的抑制作用。
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1-Methylisatin 3-thiosemicarbazone treatment of NZB x NZW hybrid mice.1-甲基异靛红3-硫代半卡巴腙对新西兰黑鼠与新西兰白鼠杂交小鼠的治疗
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THE INFLUENCE OF ISATIN BETA-THIOSEMICARBAZONE ON THE DEVELOPMENT OF NEUROVACCINIA VIRUS IN CELLS AS SHOWN BY ELECTRON MICROSCOPY.电子显微镜显示异烟腙对细胞中牛痘病毒发育的影响
Arch Gesamte Virusforsch. 1964 Jun 17;14:650-6. doi: 10.1007/BF01555122.
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Pilot trial of an antiviral agent in malignant disease.一种抗病毒药物在恶性疾病中的初步试验。
Br Med J. 1966 Sep 10;2(5514):625-7. doi: 10.1136/bmj.2.5514.625.
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The inhibition of vaccinia virus multiplication by isatin-beta-thiosemicarbazone.异烟肼-β-硫代半卡巴腙对痘苗病毒增殖的抑制作用。
Proc Natl Acad Sci U S A. 1965 Sep;54(3):946-53. doi: 10.1073/pnas.54.3.946.
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Particles resembling murine leukaemia virus in New Zealand black mice.新西兰黑鼠体内类似鼠白血病病毒的颗粒。
Clin Exp Immunol. 1968 Mar;3(3):213-26.
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J Exp Med. 1968 Mar 1;127(3):507-22. doi: 10.1084/jem.127.3.507.
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Methisazone in prevention of variola minor among contacts.甲吲噻腙在接触者中预防轻型天花的应用
Lancet. 1965 Nov 13;2(7420):976-8. doi: 10.1016/s0140-6736(65)92840-0.
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