Gabriel R
Br J Exp Pathol. 1971 Jun;52(3):271-5.
Female B/W mice have been treated with the anti-viral agent 1-Methylisatin 3-Thiosemicarbazone. The drug was given upon the day of birth and weekly until death. There was a delay in the development of proteinuria and positive antinuclear factor. The mean survival of the group was prolonged; eventually all mice died from nephritis within a 6 week period. The results are interpreted as a suppression of viral activity in these animals.
雌性黑白花小鼠已接受抗病毒药物1-甲基异靛蓝3-硫代半卡巴腙的治疗。该药物在出生当天给药，每周给药一次直至死亡。蛋白尿和抗核因子阳性的发展出现延迟。该组小鼠的平均生存期延长；最终所有小鼠在6周内死于肾炎。这些结果被解释为该药物对这些动物体内病毒活性的抑制作用。
