Stenhouse A C
Br Med J. 1968 Aug 3;3(5613):287-90. doi: 10.1136/bmj.3.5613.287.
A controlled prospective study was made of a group of patients with chronic bronchitis, in which serum antibodies against a group of viruses and Mycoplasma pneumoniae were estimated at regular intervals. Sixteen significant rises in antibody titre were shown, of which eight were associated with clinical acute exacerbations of bronchitis. In individual patients no correlation was found between the number of acute exacerbations or the aetiological agent and persistent change in ventilatory function as expressed by the F.E.V.(0.75).This study was compared with the results of a previous parallel investigation of the same patients done to study the significance of rhinovirus infections. In the present investigation 12% of the acute exacerbations were associated with the 11 agents tested compared with 14% associated with rhinoviruses in the earlier work.
对一组慢性支气管炎患者进行了一项对照前瞻性研究，定期检测他们针对一组病毒和肺炎支原体的血清抗体。结果显示抗体滴度有16次显著升高，其中8次与支气管炎的临床急性加重相关。在个体患者中，未发现急性加重次数或病原体与以第一秒用力呼气量（F.E.V.（0.75））表示的通气功能持续变化之间存在相关性。本研究与之前对同一组患者进行的平行调查结果进行了比较，之前的调查旨在研究鼻病毒感染的意义。在本次调查中，12%的急性加重与所检测的11种病原体有关，而在早期研究中，14%的急性加重与鼻病毒有关。
