顺式和反式苊-1,2-二醇的微粒体环裂变
Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol.
作者信息
Hopkins R P
出版信息
Biochem J. 1968 Jul;108(4):577-82. doi: 10.1042/bj1080577.
Abstract
- The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD(+) was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9.4 for the oxidation of the cis-diol and 9.8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.
摘要
- 研究了大鼠肝微粒体对顺式和反式苊-1,2-二醇的开环反应。2. 在二醇经微粒体孵育后，检测并分离出了1,8-萘二甲酸。3. 用分光光度法跟踪伴随的NAD(+)还原过程。4. 微粒体反应的最适pH值，顺式二醇氧化时为9.4，反式二醇氧化时为9.8。5. 对氯汞苯甲酸和2,4-二氯苯酚抑制该反应。6. 讨论了涉及1,8-萘二醛的微粒体开环反应的可能机制。
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