有毒物质的生化研究。顺式和反式苊-1,2-二醇的代谢环裂变。
Biochemical studies of toxic agents. Metabolic ring-fission of cis- and trans-acenaphthene-1,2-diol.
作者信息
Hopkins R P, Young L
出版信息
Biochem J. 1966 Jan;98(1):19-24. doi: 10.1042/bj0980019.
Abstract
- The metabolism of cis- and trans-acenaphthene-1,2-diol has been studied after the administration of these compounds to rats by subcutaneous injection and by stomach tube. 2. 1,8-Naphthalic acid has been isolated as its anhydride from the urine of the dosed animals. 3. A spectrophotometric method for the determination of free and conjugated 1,8-naphthalic acid in urine has been developed and has been used in the study of the metabolism of the acenaphthene-1,2-diols. 4. The urine of rats dosed with cis-acenaphthene-1,2-diol by subcutaneous injection was shown by paper chromatography to contain both cis- and trans-acenaphthene-1,2-diol. Similar findings were obtained after the subcutaneous injection of trans-acenaphthene-1,2-diol.
摘要
- 通过皮下注射和胃管给药将顺式和反式苊烯-1,2-二醇给予大鼠后，对其代谢情况进行了研究。2. 已从给药动物的尿液中分离出1,8-萘二甲酸酐形式的1,8-萘二甲酸。3. 已开发出一种分光光度法用于测定尿液中游离和结合的1,8-萘二甲酸，并已用于苊烯-1,2-二醇代谢的研究。4. 纸色谱法显示，皮下注射顺式苊烯-1,2-二醇的大鼠尿液中同时含有顺式和反式苊烯-1,2-二醇。皮下注射反式苊烯-1,2-二醇后也得到了类似的结果。
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