Adams R, Nelson J D
Appl Microbiol. 1968 Oct;16(10):1570-4. doi: 10.1128/am.16.10.1570-1574.1968.
Three cephalosporin-related antibiotics and nine other antimicrobial agents were studied for in vitro effectiveness against 54 recently isolated strains of Salmonella. Minimal inhibitory concentrations determined by the plate dilution method demonstrated the following percentages of resistance: ampicillin, 6%; tetracycline, 13%; streptomycin, 52%; sulfadiazine, 94%; cephaloglycin, 96%; and lincomycin, 100%. No strains were resistant to cephalothin, cephaloridine, chloramphenicol, colistimethate, kanamycin, and polymyxin B. The commonest serotype studied, S. typhimurium, showed the greatest antibiotic resistance, with 21% resistant to ampicillin, 36% resistant to tetracycline, and 71% resistant to streptomycin. Cephalothin and cephaloridine were highly effective in vitro but inhibitory concentrations of 20 to 40 mug of cephaloglycin per ml were required for the majority of Salmonella strains.
对三种头孢菌素类抗生素和其他九种抗菌剂进行了研究，以检测它们对54株新分离的沙门氏菌的体外有效性。通过平板稀释法测定的最低抑菌浓度显示出以下耐药百分比：氨苄西林，6%；四环素，13%；链霉素，52%；磺胺嘧啶，94%；头孢甘氨酸，96%；林可霉素，100%。没有菌株对头孢噻吩、头孢匹林、氯霉素、粘菌素甲磺酸钠、卡那霉素和多粘菌素B耐药。研究中最常见的血清型鼠伤寒沙门氏菌显示出最高的抗生素耐药性，21%对氨苄西林耐药，36%对四环素耐药，71%对链霉素耐药。头孢噻吩和头孢匹林在体外高度有效，但大多数沙门氏菌菌株需要每毫升20至40微克头孢甘氨酸的抑菌浓度。
