Park J H, Baron S
Science. 1968 Nov 15;162(3855):811-3. doi: 10.1126/science.162.3855.811.
A study was undertaken in rabbits to determine how late in the course of keratoconjunctivitis caused by herpes simplex recovery could be effected by an inducer of interferon. Interferon was induced by means of synthetic double-stranded RNA copolymer formed with polynosinic acid: polycytidilic acid RNA. Therapy promotes recovery from severe and fully established keratoconjunctivitis for which treatment was begun as late as 3 days after virus inoculation. No drug toxicity was observed in the therapeutic dose range. These findings further support the proposed role of the interferon mechanism in the natural recovery of already established viral infection. They also suggest the usefulness of interferon inducers in viral infections of man.
在兔子身上进行了一项研究，以确定在单纯疱疹引起的角结膜炎病程中，干扰素诱导剂能在多晚的时候影响恢复情况。通过由聚肌苷酸：聚胞苷酸RNA形成的合成双链RNA共聚物来诱导干扰素。对于在病毒接种后3天才开始治疗的严重且已完全形成的角结膜炎，该疗法能促进恢复。在治疗剂量范围内未观察到药物毒性。这些发现进一步支持了干扰素机制在已确立的病毒感染自然恢复过程中所起的作用。它们还表明干扰素诱导剂在人类病毒感染中的有用性。
