Heine J W, Galasso G J
J Virol. 1968 Oct;2(10):1147-53. doi: 10.1128/JVI.2.10.1147-1153.1968.
Infectivity of vesicular stomatitis virus was inactivated by suspending the virus in aqueous salt solutions that had previously been subjected to X-irradiation. This viral inactivation did not appear to be attributable to hydrogen peroxide or to long-lived free radicals generated by X-irradiation of the salt solutions. Indirect evidence suggested that the deleterious effects on the virus were caused by chemical species resulting from interaction of free water molecules with anions in the solution. Inactivation of infectivity was associated with distortion of the outer layer of the virion, as determined by electron microscopy, and with consequent impairment of adsorption to otherwise susceptible cells.
将水疱性口炎病毒悬浮于先前经过X射线照射的盐水溶液中，病毒的感染性被灭活。这种病毒灭活似乎并非归因于过氧化氢或盐溶液经X射线照射产生的长寿命自由基。间接证据表明，对病毒的有害影响是由游离水分子与溶液中阴离子相互作用产生的化学物质引起的。通过电子显微镜观察确定，感染性的灭活与病毒粒子外层的变形有关，并随之损害了对原本易感细胞的吸附。
