Lynch K L, Moskowitz M
J Bacteriol. 1968 Dec;96(6):1920-4. doi: 10.1128/jb.96.6.1920-1924.1968.
The toxicity of Clostridium perfringens was determined in mice utilizing three different routes of inoculation. There was marked variation in the minimum lethal dose with the different routes; the largest amount was required for the intracutaneous route, less for the intravenous route, and least with the intraperitoneal route. The relationship of toxicity to the lecithinase content of different toxin preparations was assayed. It was found that the toxicity of toxin preparations in different states of purification was not correlated with their lecithinase content.
利用三种不同接种途径在小鼠中测定产气荚膜梭菌的毒性。不同途径的最小致死剂量存在显著差异；皮内途径所需剂量最大，静脉途径较少，腹腔途径最少。测定了毒性与不同毒素制剂卵磷脂酶含量的关系。发现处于不同纯化状态的毒素制剂的毒性与其卵磷脂酶含量无关。
