McCormick W, Penman S
J Virol. 1968 Sep;2(9):859-64. doi: 10.1128/JVI.2.9.859-864.1968.
The replication of mengovirus in HeLa cells preinfected with poliovirus in the presence of 10(-3) M guanidine was investigated. Although host cell protein synthesis is inhibited by the presence of nonreplicating poliovirus, it is found that mengovirus ribonucleic acid (RNA) and protein synthesis proceed normally under the same conditions. Furthermore, no effects on mengovirus growth by poliovirus can be detected either when Mengo protein synthesis is interrupted by Acti-Dione or when its RNA synthesis is reduced by incubation at 28 C. It is suggested that the poliovirus inhibitory factor may be able to distinguish between an RNA element required in the protein-synthesizing apparatus of the host cell and a comparable element in that of the heterologous virus.
研究了在存在10⁻³M胍的情况下，脑心肌炎病毒在预先感染脊髓灰质炎病毒的HeLa细胞中的复制情况。尽管非复制性脊髓灰质炎病毒的存在会抑制宿主细胞蛋白质合成，但发现在相同条件下，脑心肌炎病毒核糖核酸（RNA）和蛋白质合成正常进行。此外，当放线菌酮中断脑心肌炎病毒蛋白质合成或在28℃孵育使其RNA合成减少时，均未检测到脊髓灰质炎病毒对脑心肌炎病毒生长有影响。提示脊髓灰质炎病毒抑制因子可能能够区分宿主细胞蛋白质合成装置中所需的RNA元件和异源病毒中的类似元件。
