Chaudhry I M, Meyer J
J Nutr. 1979 Feb;109(2):316-20. doi: 10.1093/jn/109.2.316.
Studies in several laboratories have shown that nutritional Zn deficiency in the rat causes a reduction in the activity of certain Zn-dependent enzymes in kidney, intestine, pancreas, etc. The present report deals with the effects of Zn-deficiency on submandibular gland of the rat. For the sake of comparison with previous studies, some assays on pancreas were included. Protein content, DNA, acid phosphatase, and acid protease activities were not affected in submandibular gland. Lactate dehydrogenase was unaffected in submandibular gland and showed increased activity in pancreas. Malate dehydrogenase was significantly decreased in both organs, the decrease being more marked in submandibular gland. Alkaline phosphatase activity in submandibular glands of control rats was about 10-fold higher than in pancreas. In the zinc-deficient rats, alkaline phosphatase was reduced to 59% of controls in the submandibular glands and to about 75% in pancreas. It is known from histochemical studies that in the submandibular gland this enzyme is confined to the myoepithelial cells. Recent studies attribute to salivary glands a role in the etiology of taste disturbances seen in clinical states of zinc deficiency. It is proposed that functional impairment of the myoepithelial cells might contribute to the disturbance of taste.
多个实验室的研究表明，大鼠体内营养性锌缺乏会导致肾脏、肠道、胰腺等器官中某些依赖锌的酶的活性降低。本报告探讨锌缺乏对大鼠下颌下腺的影响。为了与先前的研究进行比较，还对胰腺进行了一些检测。下颌下腺的蛋白质含量、DNA、酸性磷酸酶和酸性蛋白酶活性均未受影响。乳酸脱氢酶在下颌下腺中未受影响，在胰腺中活性增加。苹果酸脱氢酶在两个器官中均显著降低，在下颌下腺中的降低更为明显。对照大鼠下颌下腺中的碱性磷酸酶活性比胰腺中的高约10倍。在缺锌大鼠中，下颌下腺中的碱性磷酸酶降至对照组的59%，胰腺中的降至约75%。从组织化学研究可知，在下颌下腺中，这种酶局限于肌上皮细胞。最近的研究认为，唾液腺在锌缺乏临床状态下出现的味觉障碍病因中起作用。有人提出，肌上皮细胞的功能受损可能导致味觉障碍。
