Simon J, Rosselin G
J Nutr. 1979 Apr;109(4):631-41. doi: 10.1093/jn/109.4.631.
The effects of training to various rhythms of intermittent total starvation (ITS) or intermittent protein starvation (IPS) on the plasma glucose and the plasma insulin levels were studied in the growing chicken. Both types of feeding improved the glucose tolerance in spite of a decrease in the insulin response. After an oral glucose load, plasma free fatty acids showed opposite variations to plasma insulin and plasma glucose. The insulin released in response to a test meal was unchanged. In the ITS 1-1 group (1 day fasting-1 day feeding cycles), low glycemia-low insulinemia were observed during the fasting period of the cycle and high glycemia-hyperinsulinemia during the repletion period in response to the "adaptive hyperphagia." In the IPS 1-1 group (1 day feeding with the protein free diet-1 day feeding with the balanced diet cycles), glycemia was sustained at a high level during both periods of the cycle and insulinemia was depressed by feeding with the protein-free diet and highly stimulated by refeeding with the balanced diet. Therefore, in the chicken, intermittent feeding increases the insulin sensitivity of target tissues and modifies the B-cell sensitivity to glucose. The highest decrease in B-cell sensitivity to glucose was obtained with the protein free diet which further emphasizes the glucose-amino acid synergism previously observed for insulin release.
在生长中的鸡身上研究了按照不同节律进行间歇性完全饥饿（ITS）或间歇性蛋白质饥饿（IPS）训练对血浆葡萄糖和血浆胰岛素水平的影响。尽管胰岛素反应有所下降，但两种喂养方式均改善了葡萄糖耐量。口服葡萄糖负荷后，血浆游离脂肪酸与血浆胰岛素和血浆葡萄糖呈现相反的变化。对测试餐产生反应而释放的胰岛素未发生改变。在ITS 1-1组（1天禁食-1天喂食循环）中，在循环的禁食期观察到低血糖-低胰岛素血症，而在补充期，由于“适应性多食”则出现高血糖-高胰岛素血症。在IPS 1-1组（1天喂食无蛋白饮食-1天喂食平衡饮食循环）中，在循环的两个时期血糖均维持在高水平，喂食无蛋白饮食时胰岛素血症降低，而喂食平衡饮食再次喂食时胰岛素血症受到高度刺激。因此，在鸡中，间歇性喂养可提高靶组织的胰岛素敏感性，并改变B细胞对葡萄糖的敏感性。使用无蛋白饮食时，B细胞对葡萄糖的敏感性下降最为明显，这进一步强调了先前观察到的葡萄糖-氨基酸对胰岛素释放的协同作用。
