Karmali M A, Fleming P C
J Pediatr. 1979 Apr;94(4):527-33. doi: 10.1016/s0022-3476(79)80004-9.
In 37 children with Campylobacter enteritis seen over a 6-month period, ages ranged from 2 weeks to 15 years. The sex ratio (male:female) was three:two. Fever, diarrhea, and bloody stools occurred in about 90% of patients. Blood appeared in the stools characteristically 2 to 4 days after onset of symptoms. Over 90% of older children developed abdominal pain. Vomiting was mild and occurred in 30% of patients. Dehydration was not a feature. Infection occurred in all social classes and was not associated with parental occupation, travel, or animal contact. The illness often presented characteristically and a rapid laboratory diagnosis could be made in patients presenting acutely by direct phase-contrast microscopy of stools. The organism persisted in the stools for up to seven weeks in untreated patients, but could no longer be cultured after 48 hours of therapy with erythromycin, to which all strains were highly sensitive. Significant serologic responses were elicited using a serum bactericidal assay. The Skirrow-type selective medium used by us could be improved by increasing the concentration of polymyxin B sulfate to 5 microgram/ml.
在为期6个月期间所见到的37例弯曲杆菌肠炎患儿中，年龄从2周龄至15岁不等。男女比例为3:2。约90%的患者出现发热、腹泻和血便。症状出现后2至4天，粪便中典型地出现血液。超过90%的大龄儿童出现腹痛。呕吐症状较轻，30%的患者出现呕吐。未出现脱水症状。所有社会阶层均有感染发生，且与父母职业、旅行或动物接触无关。该病通常有典型表现，对于急性发病的患者，通过粪便直接相差显微镜检查可快速做出实验室诊断。在未经治疗的患者中，该病菌在粪便中可持续长达7周，但在用红霉素治疗48小时后便无法再培养出病菌，所有菌株对红霉素均高度敏感。使用血清杀菌试验可引发显著的血清学反应。我们所使用的斯基罗（Skirrow）型选择性培养基可通过将硫酸多粘菌素B的浓度提高至5微克/毫升加以改进。
