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Metabolic structure-activity relationship for a homologous series of phenacetin analogs.

作者信息

Kapetanović I M, Strong J M, Mieyal J J

出版信息

J Pharmacol Exp Ther. 1979 Apr;209(1):20-4.

PMID:430375
Abstract
摘要

相似文献

1
Metabolic structure-activity relationship for a homologous series of phenacetin analogs.非那西丁类似物同系物的代谢构效关系。
J Pharmacol Exp Ther. 1979 Apr;209(1):20-4.
2
Structure-activity relationship for deacetylation of a homologous series of phenacetin analogs and their N-hydroxy derivatives.一系列非那西汀类似物及其N-羟基衍生物脱乙酰化的构效关系。
Drug Metab Dispos. 1983 Sep-Oct;11(5):471-6.
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Metabolism of [p-18O]-phenacetin: the mechanism of activation of phenacetin to reactive metabolites in hamsters.
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4
Effect of 3-methylcholanthrene treatment on phenacetin O-dealkylation in several inbred mouse strains.
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5
A simple high-pressure liquid chromatographic assay for the N-hydroxy derivatives of phenacetin, acetaminophen, 2-acetylaminofluorene, and other hydroxamic acids.一种用于检测非那西丁、对乙酰氨基酚、2-乙酰氨基芴及其他异羟肟酸的N-羟基衍生物的简单高效液相色谱分析法。
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6
Microbial models of mammalian metabolism: biotransformations of phenacetin and its O-alkyl homologues with Cunninghamella species.哺乳动物代谢的微生物模型:非那西丁及其O-烷基同系物与小克银汉霉菌的生物转化
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Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.
Jpn J Cancer Res. 1987 Feb;78(2):153-61.
8
Comparative metabolic studies of phenacetin and structurally-related compounds in the rat.大鼠体内非那西丁及结构相关化合物的比较代谢研究。
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Hydroxylation of phenacetin by beagle liver microsomes.
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Mechanism of species differences in N-hydroxyphenacetin mutagenicity: the role of deacetylation by rat and hamster liver microsomes.
Chem Pharm Bull (Tokyo). 1984 Nov;32(11):4525-31. doi: 10.1248/cpb.32.4525.

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Development of quantitative structure-pharmacokinetic relationships.定量构效关系的发展。
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